Pfizer Senior Associate Scientist, BioMedicine Design in Andover, Massachusetts
The Sr. Associate Scientist in BioMedicine Design will w ork under supervision of Senior Scientist or higher. Assist with the development of robust and reliable ligand binding and cell-based assays suitable for characterizing the disposition (PK) and Immunogenicity of biotherapeutics in various matrixes using a range of potential platforms and assay techniques. Deliver drug concentration and immunogenicity data to PDM BioTX principle investigators. Assist with development and validation of assays to be governed per departmental SOP. Engage in accurate execution and documentation of bioanalytical methods in a regulatory compliant manner. Ensure GLP/GCP compliance is maintained in laboratory during study support. Provide Bioanalysis for Biotherapeutic compounds, under the guidance of a bioanalytical principal investigator. This includes the development and implementation of ligand binding assays (e.g. ELISA, ECL detection) to measure compound concentration, detection the presence of anti-drug antibody and neutralizing anti-product antibody activity in a regulated environment; The design, development and implementation of appropriate cell-based assays; Data analysis and interpretation and drawing conclusions regarding progress and results of work; Gathering input from PDM colleagues, other departments, literature, and additional resources to assist in driving the project forward
Design, develop and implement ligand binding assays (e.g. ELISA, ECL detection) in biological matrix (plasma, serum) to measure compound concentration, detect the presence of anti-drug antibody and neutralizing anti-product antibody activity in a regulated (GLP, GCP) environment.
Perform data analysis and interpretation and be able to draw conclusions regarding progress and results of work, utilizing the data in appropriate decision making.
Gathers input from colleagues, literature, and additional resources to assist in driving the project forward.
BS, MS or foreign degree equivalent in Chemistry, Biology or related field with 2-4 years of experience in the job offered or a related occupation.
Knowledge and hands-on experience developing ligand binding assays, utilizing various platforms.
Experience working within Good Laboratory Practices (GLP) or Good Clinical Practices (GCP) guidelines
Experience with Meso Scale Discovery (MSD) ECL platform;
Laboratory Information Management System (LIMS)
ADDITIONAL OFFER DETAILS
Last Date to Apply for Job: October 26, 2017
This job is Pfizer Exempt US Grade: 004
Location Information: Andover, MA
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