Pfizer Senior Associate Scientist in Andover, Massachusetts

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.

This position will be part of Pharmaceutical Research and Development. The incumbent will participate in the development of parenteral formulation for biologics modalities such as monoclonal antibodies, antibody drug conjugates, proteins, vaccines, cell-based therapies and viral vectors for genomic therapeutics. This position will be responsible for performing analytical characterization of candidate molecules by using various biophysical and biochemical characterization techniques. Furthermore this position will assist in developing processes for drug product manufacturing, responsible for data compilation, data presentations and report writing.

The responsibilities of Associate Scientist position include but are not limited to :

• Participate in developing parenteral formulations for biotherapeutic modalities such as monoclonal antibodies, antibody drug conjugates, proteins, vaccines, cell-based therapies and viral vectors for genomic therapeutics. This position will be responsible to assist in developing manufacturing processes (under general supervision).

• Perform rapid, comprehensive characterization of candidate molecules to determine the stability profile and applying this information to develop an appropriate dosage form to meet clinical needs. This will be achieved by applying various biophysical and biochemical techniques such as HPLC (SE-HPLC, IEX, RP-HPLC), SDS-PAGE, Capillary Gel electrophoresis (CGE),imaged Capillary Electrophoresis (iCE), Spectroscopy techniques such as UV and Fluorescence spectroscopy, Circular Dichroism and FTIR.

• The incumbent will assist in the development and scale-up of drug product processes from bench top to pilot scale and, as required, technology transfer to commercial plants. Examples of drug product processes are fluid transport, sterilizing filtration and lyophilization.

• The Senior Associate Scientist must be able to interact effectively with a multi-disciplinary team of scientists for formulation optimization and overall candidate progression.

• This position will be responsible for preparing data summary presentation, compiling data and authoring technical reports.

Effective communication skills are desirable for interactions with laboratory scientists, project managers and colleagues from numerous functions, serving on multi-disciplinary project teams.

Educational Background

Minimum:

B.S. in Pharmaceutics, Chemistry, Chemical/Biochemical Engineering, Pharmacy, Biochemistry or equivalent with 3 or more years' experience

Desirable:

M.S in Pharmaceutics, Chemistry, Chemical/Biochemical Engineering, Pharmacy, Biochemistry or equivalent with 0-3 years' experience

Work Experience/skills

Minimum: Newly qualified or up to 3 years industrial experience in parenteral formulation and process development of protein/peptide/vaccine therapeutics.

Desirable: Knowledge of drug development processes for progression of a biological candidate.

Technical Skills

Essential:

• Experience with biotherapeutics analytical methods such as HPLC (SE-HPLC, IEX, RP-HPLC), SDS-PAGE, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), spectroscopy techniques

• Demonstrated scientific documentation skills

Desirable:

• Familiarity with GMP requirements.

• Familiarity with parenteral manufacturing requirements, container/closure integrity, and commercial unit operations.

• Practical knowledge of lyophilization and lyophilization cycle development is preferred.

Familiarity in scale-up and technology transfer to pilot/commercial scale.A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.