Pfizer Group Leader, Antibody Engineering, Phage Display in Boston, Massachusetts
We are currently seeking an experienced and highly motivated Associate Director / Group Leader with hands-on experience in antibody discovery to join the Biotherapeutic Engineering and Modality Optimization group in the BioMedicine Design department of Pfizer. The candidate will lead a group of scientists working on the development of biotherapeutics in collaboration with various disease areas. The successful candidate will be responsible for designing and executing the strategy of antibody generation from phage display libraries, lead antibody optimization efforts employing advanced molecular biology, biochemistry and cell biology techniques. Functional responsibilities will also include antibody lead engineering and format optimization (bispecific and multispecific) to support several biologics programs across multiple therapeutic areas. Well-qualified candidates will have a track record of scientific accomplishments as evidenced by a strong publication record, patents and pipeline contributions. The candidate should exhibit excellent communication and collaboration skills for working on cross-functional multi-disciplinary teams.
The ideal candidate would also have prior experience leading antibody discovery projects, have hands-on management of direct reports and be flexible to work at the bench as needed. The candidate is expected to be up-to-date on advanced technologies for antibody discovery and actively apply new concepts as appropriate to continuously improve functional area capabilities.
The candidate will oversee antibody generation efforts using display technologies and other emerging technologies for affinity maturation, and developability improvements;
Ensure timely delivery of antibody therapeutics to preclinical and clinical development in collaboration with Research Units at Pfizer and with external partners;
Build productive collaborations with biology scientists from Oncology, Inflammation &Immunology and Center for Therapeutic Innovation departments; co-lead multidisciplinary project teams;
Actively participate, advice, and present to project teams and at leadership team meetings
Contribute to technology development across BioMedicine Design
Act as a departmental representative, team lead and point of accountability on several programs.
Ph.D. in Biochemistry/Cell Biology/Immunology or a related discipline with 5+ years of research experience in Biotech/Pharmaceutical environment, a record of significant achievements in research, scientific creativity, excellent communication and leadership skills and ability to work in a multidisciplinary, team-oriented environment.
Previous experience managing direct reports with a proven track record of developing careers
Hands-on work experience in antibody engineering, affinity optimization with strong understanding of protein structure-function relationships
Demonstrated track record in the development of biotherapeutics from discovery to lead optimization, expertise in the application of high throughput experimental approach driven protein optimization
Familiarity with biotherapeutic format optimization, bi-functional scaffolds and antibody-drug conjugates
Knowledge in antibody structural modeling and sequence prediction to improve antibody functions is required
Track record of scientific accomplishments as evidenced by a strong publication record, patents and pipeline contribution.
Additional Offer Details:
Last Date to Apply for Job: 9/13/2017
Additional Location Information: Boston, MA; Cambridge, MA
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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