Pfizer Group Leader, Antibody Engineering, Phage Display in Boston, Massachusetts

We are currently seeking an experienced and highly motivated Associate Director / Group Leader with hands-on experience in antibody discovery to join the Biotherapeutic Engineering and Modality Optimization group in the BioMedicine Design department of Pfizer. The candidate will lead a group of scientists working on the development of biotherapeutics in collaboration with various disease areas. The successful candidate will be responsible for designing and executing the strategy of antibody generation from phage display libraries, lead antibody optimization efforts employing advanced molecular biology, biochemistry and cell biology techniques. Functional responsibilities will also include antibody lead engineering and format optimization (bispecific and multispecific) to support several biologics programs across multiple therapeutic areas. Well-qualified candidates will have a track record of scientific accomplishments as evidenced by a strong publication record, patents and pipeline contributions. The candidate should exhibit excellent communication and collaboration skills for working on cross-functional multi-disciplinary teams.

The ideal candidate would also have prior experience leading antibody discovery projects, have hands-on management of direct reports and be flexible to work at the bench as needed. The candidate is expected to be up-to-date on advanced technologies for antibody discovery and actively apply new concepts as appropriate to continuously improve functional area capabilities.


  • The candidate will oversee antibody generation efforts using display technologies and other emerging technologies for affinity maturation, and developability improvements;

  • Ensure timely delivery of antibody therapeutics to preclinical and clinical development in collaboration with Research Units at Pfizer and with external partners;

  • Build productive collaborations with biology scientists from Oncology, Inflammation &Immunology and Center for Therapeutic Innovation departments; co-lead multidisciplinary project teams;

  • Actively participate, advice, and present to project teams and at leadership team meetings

  • Contribute to technology development across BioMedicine Design

  • Act as a departmental representative, team lead and point of accountability on several programs.


Ph.D. in Biochemistry/Cell Biology/Immunology or a related discipline with 5+ years of research experience in Biotech/Pharmaceutical environment, a record of significant achievements in research, scientific creativity, excellent communication and leadership skills and ability to work in a multidisciplinary, team-oriented environment.

  • Previous experience managing direct reports with a proven track record of developing careers

  • Hands-on work experience in antibody engineering, affinity optimization with strong understanding of protein structure-function relationships

  • Demonstrated track record in the development of biotherapeutics from discovery to lead optimization, expertise in the application of high throughput experimental approach driven protein optimization

  • Familiarity with biotherapeutic format optimization, bi-functional scaffolds and antibody-drug conjugates

  • Knowledge in antibody structural modeling and sequence prediction to improve antibody functions is required

  • Track record of scientific accomplishments as evidenced by a strong publication record, patents and pipeline contribution.

Additional Offer Details:

  • Last Date to Apply for Job: 9/13/2017

  • Grade: 14

  • Additional Location Information: Boston, MA; Cambridge, MA

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

EEO & Employment Eligibility

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A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.