Pfizer Principal Scientist, AAV Assay Lead in Cambridge, Massachusetts

About Pfizer

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description

The Gene Therapy Translational Research group is part of Pfizer's Rare Disease Research Unit (RDRU) focused on gene therapy specific platform technologies towards the delivery of IND-approved vectors for testing in clinical trials. The Principal Scientist will manage 2-4 lab-based scientists working on AAV in vitro cell based assays.


  • Manage a group of 2-4 lab-based scientists responsible for establishing and performing cell based assays related to delivering AAV gene therapy vectors for testing in clinical trials. * Perform and oversee AAV assay development for neutralizing antibodies (Nab), potency, and infectivity assays.* Partner with colleagues working on Gene Therapy projects, e.g. RDRU Biology, I&I RU and IMRU colleagues, PDM, PharmSci, CDX and CAG colleagues.* Evaluate and engage external collaborators and Contract Research Laboratories (CROs).


  • Ph.D. or Masters Degree in the life sciences with 5 year's relevant experience in cell based assays.* Cell culture expertise (primary and immortalized).* Evidence of scientific accomplishments in the form of publications and presentations.* Evidence of mentorship and supervisory experience required.* Exceptional communication skills and demonstrated ability to work effectively as part of a team.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Principal Scientist, AAV Assay Lead Cambridge, Massachusetts 1054102-1852