Pfizer Principal Scientist, Antibody Engineering in Cambridge, Massachusetts


This position will be part of a Biotherapeutic Engineering and Modality Optimization group (BioMedicine Design) responsible for antibody engineering as applied to biological therapeutics across different research units at Pfizer. A successful candidate will have a solid immunology background with demonstrated experience in developing biologics for immune modulation to treat diseases. S/he will also have a thorough knowledge of principles of antibody engineering and methods in primary cell-based immunological assays, project leadership with strong collaborative and communication skills, proactive attitude and an awareness of current trends and technologies.


  • Conduct and guide junior scientists in multi-color/multi-parameter high throughput flow cytometry experiments using directly labeled antibodies and/or secondary conjugated flurophores and competency in analysis of data using FlowJo software

  • Design, develop and optimize cell based functional assays (immunology assays using primary cells), for antibody screening (e.g. signaling inhibition/activation, proliferation, cytotoxicity) and analysis with software such as GraphPad Prism. Apply robust statistical analyses to data

  • Engineer and develop multispecific antibody modalities to generate combinatorial therapies

  • Serve as a Biotherapeutic lead on projects in a cross-functional team setting and act as a champion for the BioMedicine Design group

  • Act as a liaison and forge collaborative relationships between BMD and other research units and contribute to target validation for biotherapeutic development

  • Contribute to authorship of technical reports for patent applications, IND reports and scientific publications

  • Take active role in coaching and mentoring direct reports. Provide supervision and guidance in day-to-day activities and act as champion to further career development


  • Experience with antibody engineering in developing immunotherapeutics

  • Flow cytometry based cell sorting and other cell based assays

  • Prior supervisory experience

Education and Experience

M.S./Ph.D. in Biochemistry/Cell Biology/Immunology or a related discipline with 5+ years of research; Experience in academia and/or Biotech/Pharmaceutical environment; A record of significant achievements in research; Scientific creativity; Excellent communication and leadership skills and the ability to work in a multidisciplinary, team-oriented environment.

  • Hands-on work experience in antibody discovery and engineering. Experience in project leadership is highly desirable

  • Demonstrated experience in the design and testing of biotherapeutics from discovery to lead optimization

  • Technical expertise in establishment and validation of cell surface receptor binding assays, internalization by FACS, ELISA and other cell based assays

  • Strong interpersonal skills, demonstrated ability to work in a highly collaborative environment and ability to achieve high quality results

  • Ability to work in agile environment and adapt to change

  • Excellent communication and organizational skills

  • Self-motivated and adept at regularly delivering towards deadlines.

  • Strong skills in troubleshooting

  • Take initiative readily and further develop expertise as needed; stay current on relevant literature


  • Comfortable working in a fast-paced team environment while multi-tasking

  • Ability to deliver impactful internal and external presentations and publications (oral, poster, journals)

  • Enthusiastic about communicating to a broad range of stakeholders (from novices to experts)

  • Curiosity about seeking and applying current relevant scientific literature toward new solutions

Additional Offer Details:

  • Last Date to Apply for Job: October 15, 2017

  • Grade: 11

  • Additional Location Information: Cambridge, MA

  • Eligible for Employee Referral Bonus

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

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A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.