Pfizer Principal Scientist, Antibody Engineering in Cambridge, Massachusetts
This position will be part of a Biotherapeutic Engineering and Modality Optimization group (BioMedicine Design) responsible for antibody engineering as applied to biological therapeutics across different research units at Pfizer. A successful candidate will have a solid immunology background with demonstrated experience in developing biologics for immune modulation to treat diseases. S/he will also have a thorough knowledge of principles of antibody engineering and methods in primary cell-based immunological assays, project leadership with strong collaborative and communication skills, proactive attitude and an awareness of current trends and technologies.
Conduct and guide junior scientists in multi-color/multi-parameter high throughput flow cytometry experiments using directly labeled antibodies and/or secondary conjugated flurophores and competency in analysis of data using FlowJo software
Design, develop and optimize cell based functional assays (immunology assays using primary cells), for antibody screening (e.g. signaling inhibition/activation, proliferation, cytotoxicity) and analysis with software such as GraphPad Prism. Apply robust statistical analyses to data
Engineer and develop multispecific antibody modalities to generate combinatorial therapies
Serve as a Biotherapeutic lead on projects in a cross-functional team setting and act as a champion for the BioMedicine Design group
Act as a liaison and forge collaborative relationships between BMD and other research units and contribute to target validation for biotherapeutic development
Contribute to authorship of technical reports for patent applications, IND reports and scientific publications
Take active role in coaching and mentoring direct reports. Provide supervision and guidance in day-to-day activities and act as champion to further career development
Experience with antibody engineering in developing immunotherapeutics
Flow cytometry based cell sorting and other cell based assays
Prior supervisory experience
Education and Experience
M.S./Ph.D. in Biochemistry/Cell Biology/Immunology or a related discipline with 5+ years of research; Experience in academia and/or Biotech/Pharmaceutical environment; A record of significant achievements in research; Scientific creativity; Excellent communication and leadership skills and the ability to work in a multidisciplinary, team-oriented environment.
Hands-on work experience in antibody discovery and engineering. Experience in project leadership is highly desirable
Demonstrated experience in the design and testing of biotherapeutics from discovery to lead optimization
Technical expertise in establishment and validation of cell surface receptor binding assays, internalization by FACS, ELISA and other cell based assays
Strong interpersonal skills, demonstrated ability to work in a highly collaborative environment and ability to achieve high quality results
Ability to work in agile environment and adapt to change
Excellent communication and organizational skills
Self-motivated and adept at regularly delivering towards deadlines.
Strong skills in troubleshooting
Take initiative readily and further develop expertise as needed; stay current on relevant literature
OTHER ATTRIBUTES DESIRABLE:
Comfortable working in a fast-paced team environment while multi-tasking
Ability to deliver impactful internal and external presentations and publications (oral, poster, journals)
Enthusiastic about communicating to a broad range of stakeholders (from novices to experts)
Curiosity about seeking and applying current relevant scientific literature toward new solutions
Additional Offer Details:
Last Date to Apply for Job: September 13, 2017
Additional Location Information: Cambridge, MA
Eligible for Employee Referral Bonus
EEO & Employment Eligibility
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A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.