Pfizer Scientist, Neurodegeneration (non in Cambridge, Massachusetts

The Lipids and Lysosomes group (Neurodegeneration) in the Pfizer Internal Medicine Research unit located in Cambridge, MA is focused on building a strong lipids and lysosome platform to develop world class therapeutics for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The successful candidate will contribute to a range of drug discovery efforts centered on identification of novel targets, pathways, and mechanisms involving the role of lipids and lysosomes and their dysfunction in neurodegeneration. The primary goals of this position will be to support project team efforts through development and validation of robust in vitro assays, evaluating in vivo models and contributing to mechanistic understanding of underlying biology.

In this position, the successful candidate will work with highly driven teams as part of a large matrix environment, collaborating with multiple groups including discovery biology and several partner lines including medicinal chemistry, PDM and the central primary pharmacology group.

The Lipids and Lysosomes lab within the Neurodegeneration group is seeking a highly motivated biologist whose primary responsibility will be to:

  • Perform laboratory experiments to help establish robust disease biology, biochemical and cell-based compound screening assays and carry out in vivo evaluation across a broad array of target classes for the project teams.

  • Operate a broad array of liquid-handling and plate-based pharmacology equipment as needed to ensure efficient automated workflows for newly developed assays.

  • Identify new mechanisms of exploration across the neurodegenerative disease landscape and integrate contemporary and cutting edge technology into a successful drug discovery program.

  • Identify and develop scientific strategies to support the goals of the Lipids and Lysosomes lab.

  • Apply innovative approaches to test hypotheses; evaluating and incorporating new science and technology to solve research problems.

  • Be a meticulous and data driven scientist, clear thinker with a passion for scientific exploration and the ability to communicate a vision and be able to work in a collaborative environment.

  • Prepare and present experimental results to project teams.

  • Maintain high quality experimental records within electronic laboratory notebook.

Qualifications:

  • BA, BS or MS in biology or neuroscience with laboratory experience relevant to this position.

  • Broad understanding of cell and molecular biology, preferably with an emphasis in Neuroscience.

  • Scientific understanding of the major target classes (GPCRs, Enzymes, transporters, ion channels, etc.)

  • Strong experience with molecular biology techniques such as RNA isolation, RT-qPCR and biochemical techniques such as protein assays and western blotting.

  • Experience with techniques such as IP-MS, ChIP-seq and ChIP-MS highly preferred.

  • Experience with assay development methodologies.

  • Experience with cell culture (primary and immortalized) and in vivo rodent models.

  • Experience with automation of liquid handling and screening workflows preferred but not mandatory.

  • Ability to conduct data analysis using Microsoft Excel, GraphPad Prism, or equivalent software.

  • Ability to complete experiments and present results in individual and group settings.

  • Proven verbal and written communication skills, and the ability to work in a collaborative team environment.

EEO Statement

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Additional Offer Details:

  • Grade: 06

  • Additional Location Information : Cambridge, MA

  • Eligible for Employee Referral Bonus

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.