Pfizer Senior Scientist Preclinical Formulation Development in Cambridge, Massachusetts

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.

The key purpose of this Senior Scientist position is to influence the early candidate substrate from a physical chemical, drug delivery and bioperformance perspective through close collaboration with partners on the Discovery project teams and in Pharmaceutical Science. You will need to act as a resident pharmaceutical science subject matter expert to inform, educate and influence Discovery teams in finding NCEs with desirable drug delivery and performance properties. This will include assessment of in silico, in vitro and in vivo data as well as design of stage appropriate formulations for preclinical studies. An awareness of later stage development needs as well as an understanding of the disease state and biology will help to enable the definition of the required design elements.

• Closely collaborate with Discovery partners to evaluate molecular attributes relevant to drug delivery and influence team strategies.

• Design and develop fit for purpose preclinical formulations (traditional and enabling) to enable robust candidate selection and progression.

• Assess and clearly communicate drug delivery and performance risks (using in silico, in vitro and in vivo data as well as sound scientific principles).

• Maintain an awareness of and contribute to scientific literature; actively apply new concepts as appropriate.

• Conduct novel research and present significant findings via internal and external presentations or publications.

• M.S. with >5 years of relevant experience or PhD in Pharmaceutics, Chemistry, Medicinal Chemistry, Physical Chemistry or Biophysics with 0-3 years of experience required.

• Facility with computational chemistry tools to predict physical properties and experience in the translation of molecular properties to predict bioperformance.

• Modeling of oral absorption phenomena and the interpretation of in vitro/in vivo ADME data.

• Experience with the design of typical formulation approaches and routes of administration across multiple species.

• Strong organizational, interpersonal, written and verbal communication skills.

• Strong scientific leadership and direction of new technology initiatives.

• Application of fundamental principles to solve complex problems

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Candidates must have the ability to perform laboratory work. Intermittent travel to Groton, Connecticut will be necessary.A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.