Pfizer Postdoctoral Fellow in Groton, Connecticut

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

We are seeking a highly qualified and energetic PhD scientist to join us as a postdoctoral researcher focused on elucidating the three dimensional structures of membrane proteins that serve as important drug transporters. The incumbent will be trained in the state-of-the-art science of membrane protein structural biology, be exposed to the drug discovery and development process, and will learn the application of structure information in drug design. At our disposal, we have extensive in-house experience and resources supporting protein expression, purification, crystallization, structure determination of both soluble and membrane-bound proteins. Presently, Pfizer scientists have regular access to all the major X-ray synchrotron beam lines in the world, in house Cryo-EM facilities, and rich collection of small molecular ligands to enable protein stabilization and crystallization. Ideal candidates should have experience in protein expression, protein purification and crystallography, and preferably less than 4 years postdoctoral experience.

  • Optimize membrane protein constructs for functional expression and protein stability.

  • Purification of functional membrane proteins for structural determinations.

  • Protein crystallization and data collection. Sample preparation for Cryo-EM and data collection. Data analysis and structure determination. Structure analysis to understand structure-function relationship.

  • Interface with scientists across lines/discipline and show strong initiative in developing ideas to assist in the design of exploratory experiments.

  • Collect up-to-date information and keep abreast of the relevant literature, data acquisition and analysis, manuscript preparation, presentation of study results in oral and poster formats.

  • Ph.D. in structural biology with extensive knowledge in molecular biology, protein chemistry and wet lab protein structural biology skills.

  • Previous experience with protein construct design, expression and purification is required.

  • Previous experience with membrane protein is a plus.

  • Previous experience in structure determination is a plus.

  • Demonstrated track record of publishing in peer-reviewed scientific journals.

  • Excellent communication skills and ability to work independently are essential.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.