Pfizer Proteomics Senior Scientist Primary Pharmacology Group in Groton, Connecticut
Pfizer colleagues have many perspectives, many backgrounds and many strengths. But we share one goal: to make the world a healthier place. Our investment in people is a commitment to strengthen an already remarkable company. Pfizer is a place for people who strive to learn, grow and lead.
The Primary Pharmacology Group (PPG) is looking for a talented Proteomics Scientist. This highly motivated technology expert will be an integral member of the Proteomics team, which supports programs across multiple research units (Cardiovascular & Metabolic disease, Inflammation and Immunology, Rare Diseases and Neuroscience). PPG plays a vital role in conducting phenotypic screening and proteomics is used to: assess the disease relevance of the screening model, understand the signaling pathways perturbed by hits from the screen, and define the molecular target of those hits. The successful candidate will play a leading role in developing, optimizing and implementing multiplexed proteomics assays in a team environment. This role is an opportunity to conduct exciting, cutting-edge science, aiming for clinical impact by contributing to the proteomics piece of the drug discovery puzzle.
Development and optimization of multiplexed (iTRAQ/TMT) proteomics methods to enable optimal design of our phenotypic screens
Characterization of mechanisms of action (protein expression, PTM and subcellular localization changes) induced by screening hits
Identifying the molecular target of hits from phenotypic screens
Analyze, interpret and communicate proteomics results
Adopt a Continuous Improvement mindset to improve quality, efficiency and/or cost of processes within the lab
Promote Pfizer proteomic capabilities and reputation through external publications and presentations.
Troubleshoot laboratory instrumentation and assays
Maintain up to date electronic laboratory notebooks and records in accordance with Pfizer policy.
Minimum qualification PhD in analytical chemistry, biochemistry or equivalent with 4+ years of relevant experience OR MS with 10+ years of industry experience.
Experience using hybrid Mass Spectrometers (LTQ-Orbitrap Elite, Orbitrap Fusion/Lumos, Q-Exactive) and liquid chromatography (nanoflow, capillary flow, affinity, reverse-phase) and fraction collection systems.
Expertise in multiplexed quantitative proteomics using iTRAQ or TMT.
Experience in PTM analysis (ubiquitination, glycosylation, tyrosine phosphorylation etc.)
Enrichment of protein families or compartments e.g. kinases, GTPases, cell-surface proteins
Experience in chemical-proteomics applications to study small molecule-protein interactions both for in-lysate and whole-cell workflows is desired.
Proteomics and PTM data analysis - processing of raw data, FDR calculation, PTM site-localization
Informatics - assessing statistical significance, cluster analysis, GSEA, motif analysis etc.
Excellent oral and written communication skills
Generation of publication quality figures
Being both teachable and willing to teach
Be a creative, independent, critical thinking, problem solver
Experience interacting with other groups outside the proteomics discipline - material management, automation, transcriptomics, metabolomics and informatics.
Highly self-motivated and goal oriented
Have a Team mindset
At Pfizer, we believe in helping people lead healthier lives - from our customers to our colleagues. We offer a wide array of programs and plans that give our colleagues the flexibility and tools they need to get and stay healthy, both physically and financially. These include competitive compensation, generous medical, vacation and retirement benefits as well as a number of additional programs.
The Primary Pharmacology group offers an exciting, fast-paced, supportive environment for colleagues, and fosters a culture encouraging openness, innovation and ownership of our science. We aim to provide continual scientific and growth opportunities for personal development commensurate with a colleague's goals and experience.
Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and to work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data .
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Travel is not required, however there will be opportunities to travel occasionally to Cambridge, MA to partner with Research Unit project teams and attend appropriate meetings and conferences.
Compliance with laboratory safety practices.
Eligible for Relocation
Eligible for Employee Referral Bonus
EEO & Employment Eligibility
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A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
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