Pfizer Senior Scientist Cryo in Groton, Connecticut
A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
The successful candidate will join the department of Structural and Molecular Sciences (SMS), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, NMR, biophysics, protein crystallography and cryo-EM. Our mission is to provide integrated molecular insights into drug targets, lead compounds and target-compound interactions to advance discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Neurosciences, Cardiovascular and Metabolic Diseases and Rare Diseases.
We have recently established a cryo-EM lab within Pfizer, equipped with a state-of-the-art FEI Titan Krios microscope with a Gatan K2 Summit direct electron detector for high resolution data collection, a FEI TF20 microscope with Gatan OneView detector for sample characterization, and a dedicated computer cluster and GPU boxes for data processing.
As a Senior Scientist, you will have experience with all aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. You will also be familiar with the hardware and computing skills associated with EM such as microscope, direct electron detector, sample robot, computer cluster, etc. and their maintenance. Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM techniques to positively impact drug discovery.
The Senior Scientist will design and perform experiments in the technical area of single particle cryo-EM.
Experimental results will be formulated computationally and will be recorded in an electronic laboratory notebook.
Prompt and clear communication will occur with project team colleagues.
External scientific publication and presentation will be encouraged when appropriate as a means of assuring optimal research standards.
• Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field.
• Postdoctoral training in cryo-EM with ca. 2-5 years of industrial or related academic experience.
• Skills in molecular biology and protein biochemistry are highly desirable.
• Proven ability to design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in top journals.
• Broad knowledge in protein characterization, biophysics, computational chemistry and medicinal chemistry will be helpful to facilitate problem-solving.
• Proven scientific influence via strong interpersonal and communication skills; passionate about using structural data to influence key scientific decisions. Has the skill and drive to grow into a thought leader.
Ability to perform laboratory research and travel
Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.