Pfizer Head of Translational Immuno in San Diego, California

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

As the head of the Translational Immuno-oncology group (TIO), the position will be responsible for conducting biomarker and mechanism of action (MOA) studies for cutting edge cancer vaccine and oncolytic virus programs. This includes preclinical discovery research and early clinical biomarker and MOA studies. The position will contribute to both operation and strategy of oncology R&;D, directly manage a team of about 5-6 translational scientists, and work closely with several partner groups, including preclinical immuno-oncology and clinical oncology teams. The position is located in La Jolla, CA, and reports to the VP for Cancer Vaccines &; Immunotherapeutics.

Lead Translational Immuno-oncology (TIO) within the Cancer Vaccines &; Immunotherapeutics Department

• Apply expertise in translational sciences to advancing cancer vaccine- and oncolytic virus-based immunotherapy regimens from preclinical research through early clinical development. This will include discovery and development of biomarker assays, therapy mechanism-of-action (MOA) studies, and contributions to the design and execution early clinical development plans to incorporate translational science components.

• Strengthen departments' overall translational immune-oncology capabilities and expertise, for example by expanding immunophenotype assays and employing new methods and technologies.

• Identify, initiate, and manage external collaborations to support translational immune-oncology research and drug development.

• Collaborate with multiple internal and external groups to design, implement, and conduct biomarker and MOA studies. Internal groups include the Oncology Research and Clinical Oncology divisions. Collaboration also involves engaging external CROs to collect biopsies and conduct biomarker assays under GLP conditions.

• Serve as TIO representative on all cancer vaccine and oncolytic virus program teams, helping to rapidly and rigorously advance development.

• Develop and ensure adherence to Standard Operating Procedures (SOPs) for patient biopsy collection and clinical biomarker assays.

• Contribute to preparation of required drug development and regulatory documents (e.g., IND submissions), being responsible for translational science components.

• Effectively communicate strategy, methodology, progress, and challenges to multiple stakeholders and partners, including senior executives and governance committees.

• Represent Pfizer at external conferences and scientific events, and publish results in high quality scientific journals.

Manage the Translational Immuno-oncology Team

• Responsible for directing of daily activities, overall performance, and career development of a team of 5-6 scientists.

• Ensure high productivity and strong scientific rigor of each TIO team member.

• Accountable for maintaining a safe working environment for TIO team members.

Contribute to Strategy and Operation of Cancer Vaccines &; Immunotherapeutics (CVIT) Department

• As a member of the CVIT Leadership Team, help to:

  • Define and implement overall CVIT research and development strategy and priorities.

  • Assign and coordinate efficient use of all resources, including staff activities and research funds.

  • Manage performance and development of entire CVIT staff.

  • Carry out various CVIT operational assignments, for example serving on safety committees or overseeing implementation of new personnel policies or lab procedures.

• May serve a Program Team Leader, accountable for all aspects of program strategy and execution

  • Work with project management and all team members to efficiently advance a research program from discovery phases through early clinical development.

  • Accountable for of high scientific rigor, expertise, and productivity of program.

  • Responsible for all communication between Program Team and stakeholders.

• MD/PhD or PhD in immunology, cancer biology or relevant biological science

• 10+ years of experience with at least 7 years in oncology drug discovery and development, including immuno-oncology experience.

• Experience in translational oncology, including preclinical identification and clinical evaluation of biomarkers (pharmacodynamics, prognostic, and response predictive).

• Strong scientific leadership experience, including experience leading multi-disciplinary project teams.

• Extensive experience in managing a staff of scientists, including maintaining high productivity and motivation, evaluating performance, and developing all direct reports.

• A strong record of achievement, including advancement of cancer drug projects and publications in leading journals.

• Outstanding communication and influencing skills.

PHYSICAL/MENTAL REQUIREMENTS

Normal physical/mental requirements for office-based scientific role

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

US travel (up to 20% time) expected as part of this role

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.