Pfizer Principal Scientist in San Diego, California

About Pfizer

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description

Pfizer Vaccine Immunotherapeutics (VITx) seeks to discover novel vaccines (prophylactic and therapeutic) for the prevention and treatment of significant human diseases (e.g. infectious diseases, oncology) using a variety of vaccine technology platforms combined with immunomodulatory agents. We are seeking a Principal Scientist in Virus Production and Purification, focusing on downstream process development, to join the Virus/Protein Sciences group in VITx, La Jolla, California, to lead the development, support and transfer of virus purification processes from pre-clinical research scale in VITx to Ph1 production scale in Pfizer, or at CMOs. The individual will have responsibility for establishing reproducible protocols for virus production/purification that fall within agreed product specifications and are accompanied by reports that could be used for IP filings, documentation required to underpin regulatory documents and/or Investigator Brochure supportive data packs. The individual will have some responsibility for technology transfer of virus production/ purification protocols to Vaccine Research Early Development, Biotherapeutics Pharmaceutical Sciences, and/or CMOs.The successful candidate will have advanced knowledge and significant experience in virus and/ or protein production/purification. In addition, the individual will have sound knowledge and training in chemical/biochemical engineering principles related to separation and purification of biologicals - preferentially live virus purification - with a proven record of leading downstream purification process development, scale-up and process transfer in an industrial setting to supply both Regulatory Toxicology and clinical trial material. The successful candidate will be required to work with BSL2 infectious viruses, e.g. Vaccinia virus, AdenovirusThe individual will be skilled in the process development, optimization and scale-up of the following:Virus production at bioreactor scaleVirus purification using chromatographic techniquesCell lysis, harvest and clarification techniquesTangential flow filtration - both ultra and microfiltrationEnzymatic digestion stepsDead-end filtrationUltracentrifugation based purification - both batch and continuous flowAdditional required skills would include one or more of the following:Experience working with BSL2 infectious viruses - e.g. Vaccinia virus, Adenovirus Virus/protein characterization techniquesViral vector and/ or vaccine development*Statistical experimental design - DOEThis role is both laboratory based and supervisory, with a major emphasis placed upon laboratory training and supervision of other scientists to maximize productivity and increase the group's skills. The individual will be required to work independently under minimal supervision to develop and manage plans to achieve project and team goals, as agreed with supervisor. The individual's specialist knowledge and skills will be transferred to other members of the group by working alongside them in the laboratory so as to ensure scientists are developed for roles with increased independence and responsibility. They will oversee the research of other scientists both directly (in their reporting line) and indirectly (in the matrix team) as project needs dictate. As a member of multi-disciplinary project teams they will represent their team and be accountable for the critical appraisal of their groups work and results and present them for review, at specific project milestones.As a supervisor/ sub-team lead in the Protein Sciences team, the individual will be responsible for coordinating their resources with the group head and other sub-team leads, and as necessary with colleagues from other VITx and/ or Pfizer groups to ensure delivery of project goals.

Responsibilities

EXPERIMENTAL/LABORATORY & RELATED WORK (50-60%):Will oversee experimental design of scientists in the virus production or purification group Will review scientist's analysis and critical interpretation of experimental data, results and methodology used.Will work with virus production or purification scientists to plan and execute a series of experimental tasks to address specific scientific objectives of the project.Will work alongside virus production or purification scientists in the lab as necessary to transfer knowledge and skills for working with state-of-the-art purification techniques.Will be an accomplished scientist with notable track record of success and problem solving in all aspects of virus production or purificationWill regularly use the scientific literature and electronic information critically to enhance understanding of disease/technology area and generate novel methods and testable hypotheses to support ongoing or start new projectsMANAGEMENTWill supervise at least 2 colleagues in the Virus/Protein Sciences group with additional matrix and contingent worker supervision as needed.Will direct daily-weekly research activities of colleagues in group in all aspects of virus production or purification to support VITx projects in the discovery and early development of novel vaccinesWill be responsible for liaising with colleagues in Vaccine Research Early Development and Biotherapeutics PharmSci for knowledge and process transfer prior to Regulatory Toxicology and clinical trial material manufacture.Will liaise with Virus/Protein Sciences group leadership and project teams to establish priorities of research deliverablesWill be responsible for constructing goals, practice real time performance management, and conduct annual performance appraisals for colleagues in the group.Will develop robust career development plans for colleagues and actively engage colleagues in career development opportunities as they ariseDOCUMENTATIONEnsure that group generates SOPs, study reports and protocols etc. in appropriate time framesEnsure that Virus/Protein Sciences group writes up electronic laboratory notebooks regularly in compliance with Pfizer IP policy and GSP.Preparation of materials for internal and external presentations capturing groups plans/achievementsCOMMUNICATIONWill have effective communication skills, both verbal and written; listens and understands well.Will regularly communicate with supervisor and team scientistsWill regularly contribute and influence at the discipline and project team level in a leadership or team member capacity.Regularly present at internal meetings/poster sessions and present and publish in the broader scientific community.SAFE WORKING AND REGULATORY COMPLIANCEWork safely themselves and be aware of EHS practices of other colleagues in all aspects of role, including handling of BSL2 infectious viruses.Ensure compliance with all EHS practices/policies for direct reports.Completion of risk assessments, compliance training as required*Acts independently to maintain a safe and EHS compliant desk and workspace

Qualifications

MSc in biological sciences or Biochemical/chemical engineering with 9 years relevant laboratory experiencePhD in biological sciences or Biochemical/chemical engineering with 4 years relevant laboratory experiencePHYSICAL/MENTAL REQUIREMENTSStandard laboratory conditions - sitting, standing, primarily lab basedAbility to lift up to 30 lbsWorking with BSL2 infectious virusesAbility to perform mathematical calculations and complex data analysisInfrequent travel (for internal and/ or external meetings and tech.transfer activities).NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTSMust receive and maintain required vaccinations or provide satisfactory proof of same.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Principal Scientist San Diego,California 1039563-1852