Pfizer Senior Scientist, Cancer Immuno in San Diego, California

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

We seek a driven and accomplished immuno-oncologist at the senior scientist level to join our Cancer Immuno-pharmacology (CIP) group in the Oncology Research &; Development unit (ORD) of Pfizer's Worldwide R&;D (WRD) division in La Jolla, California.

Participate in pre-clinical drug discovery and development projects in immuno-oncology,

focusing on small molecules alone or in combination with biologics. Work in one of the areas T and NK cell biology, myeloid cell biology, immunosuppressive mechanisms in the tumor microenvironment, reprogramming of suppressive immune cells, tumor immunogenicity and antigen presentation, or tumor barrier mechanisms. In collaboration with partner lines, contribute experimentally and scientifically to target identification, prioritization and validation, drug discovery and drug development. Employ cutting-edge in vitro and in vivo animal and human cancer models. Complement the existing CIP group and provide immunology expertise to ORD and WRD.

Organizational Relationships:

Internal: Entire ORU group, including supervisors, peers and reports. Partner lines including

PDM, DSRD, TRG, OBU, OTD, CTI, TCB, BDD, Rinat, Vaccine Group, Translational

Oncology.

External: iTeos, CROs including WuXi, HDB, Crown Bio and others. Various vendors.

• Work with a principal or senior principal scientist to develop novel small molecule cancer immunotherapeutics.

• Provide expertise in one of the areas T and NK cell biology, myeloid cell biology, immunosuppressive mechanisms in the tumor microenvironment, reprogramming of suppressive immune cells, tumor immunogenicity and antigen presentation, or tumor barrier mechanisms.

• Collaborate with Pfizer's world-class chemical biology and functional genomics groups to

identify novel mechanisms and targets limiting anti-tumor immune responses.

• Design and conduct relevant in vitro and in vivo assays and models, with particular emphasis on humanized systems. Use them to validate and prioritize targets for improving anti-tumor immune responses, and to discover and develop target-modulating compounds.

• Contribute experimentally and scientifically to all stages of pre-clinical drug discovery and development.

• Design, conduct, and guide experiments. Generate, evaluate and present data. Participate actively in due-diligence analyses, meeting reports, project team, governance and other meetings and journal clubs.

• Train colleagues in technical and scientific aspects of immuno-oncology.

• Conduct lab management activities, including equipment maintenance, ordering and lab organization.

• Interact productively with internal and external groups, cross-functional teams and initiatives.

Education and Experience:

• Ph.D. or M.D. in immunology with 1-3 yrs' experience in immunology, or a related discipline with postdoctoral experience in immuno-oncology or immunology evidenced by strong publications.

• At least 3 years of specific experience in cancer immunology.

• Strong publication record or equivalent achievements in industry.

Technical Skill Requirements:

• Proven ability to make important scientific contributions to immuno-oncology.

• Ability to stay on top of novel scientific developments and opportunities, and to identify and

quickly enter relevant new fields to make significant contributions.

• Strong expertise in one of the areas T and NK cell biology, myeloid cell biology,

immunosuppressive mechanisms in the tumor microenvironment, reprogramming of suppressive immune cells, tumor immunogenicity and antigen presentation, or tumor barrier mechanisms.

• Strong experience with in vitro and in vivo models of the tumor microenvironment, in

particular in modulating Treg cells, MDSC or M2 macrophages, in augmenting tumor

antigenicity, or in disrupting tumor barriers to improve immune cell entry.

• Proficiency in target identification, validation and mechanistic analysis.

• Ability to use multidisciplinary tumor immuno-phenotyping approaches for treatment

optimization, target discovery and validation.

• An ideal candidate has strong experience with human tissue culture systems (co-culture,

histoculture, organoids, organ-on-a-chip) and/or humanized mice.

• Excellent written and oral communication and presentation skills in English. Proficiency in all

common office and scientific software.

• Strong ability to multi-task and work efficiently and productively in a fast-paced, highly

collaborative, matrixed and diverse team environment. Capacity to contribute to a vivid and

challenging intellectual environment.

Physical/Mental Requirements:

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations, ability

to read, comprehend and process complex scientific matter, and to perform complex data

analysis. Ability to travel by air, water and ground.

Non-standard Work Schedule, Travel:

Ability to accommodate non-standard work schedules due to experimental regimen or travel.

Ability to adhere to safe work practices and wear full personal protective equipment. Ability to

travel nationally and internationally.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Colleagues who are issued an Incident Final Warning (IFW) on or after January 1, 2016, are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.