Pfizer Senior Scientist, Protein Engineering in South San Francisco, California

About Pfizer

A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description

The Protein Engineering Department is seeking an outstanding Senior Scientist to lead protein engineering and technology development projects. The candidate will be responsible for working closely with individuals in both protein engineering and immunology/oncology groups to innovate, develop and characterize the next generation of protein therapeutics for cancer treatment. The candidate will have access to state of the art protein and antibody engineering technologies and will be expected to continue our tradition of developing world class methods and technologies that enhance our therapeutic discovery efforts.


The primary responsibilities include obtaining in-depth knowledge of the therapeutic targets of interest; design creative antibody/protein based therapeutics and characterizes their functionalities in cell based assays. This position requires the candidate to carry out hand-on lab work to apply protein engineering principles to generate novel protein therapeutics and use biochemical/cell biology principles to characterize them in vitro. The ideal candidate needs to have a strong understanding on how to engineer and characterize protein therapeutics. This work will also include close collaborations with biologists to design and evaluate different protein therapeutics of interest. The candidate needs to demonstrate strong desire and initiative to understand immunology and tumor biology, and help propose new ideas and techniques to discover next-generation therapeutics with unique functionalities.


Ph.D. in Biological Science (Molecular Biology, Structural Biology, Protein Biochemistry, Cell Biology) or a related field (Chemical Engineering, Biomedical Engineering and Biological Engineering)At least 2 years of post-graduate experience in either an academic or industrial setting is preferredStrong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation.Track record of demonstrating analytical skills, creativity and unique problem solving skillsOutstanding pro-active attitude, interpersonal, collaborative and oral communication skillsStrong motivation, passion and commitment to science and engineering novel entitiesAbility and desire to work in an interdisciplinary scientific team and the desire to learn new techniquesAbility to analyze and interpret work published in the field and apply it appropriatelyTechnical expertise should include molecular biology and protein biochemistry, screening protein libraries, ELISA, FACS, and/or other biochemical and cell based assaysPrior experience in working with immune system derived proteins is preferredPrior experience in the in vitro characterization, e.g. activity, trafficking, signaling, is preferredPrevious experience with protein engineering techniques such as phage display and yeast display would be a plusPrior experience in protein modeling and analyzing protein structures would be a plusKnowledge of translational work involving antibody and protein therapeutics in immunology and oncology would be of significant advantagePHYSICAL/MENTAL REQUIREMENTS This is a bench scientist position in the field of cell/molecular biology and protein engineering. All the physical requirements for cloning, expressing, purifying proteins, cell base assays are required.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Senior Scientist, Protein Engineering South San Francisco, California 1053525-1293