Pfizer Senior Principal Scientist, Biophysics Group Lead in Andover, Massachusetts
Biophysics Senior Principal Scientist/Group Leader; Pfizer, Andover, MA
The process and product development organization, Biotherapeutics Pharmaceutical Sciences, is seeking a Ph.D., M.S. or B.S. level candidate specializing in protein chemistry, higher-order structure, molecular association, and biological function to lead and manage a laboratory-based group of experienced biophysicists. As part of the Analytical Research and Development (ARD) department, the qualified candidate will lead and foster the development and implementation of contemporary biophysical strategies, techniques and methods for the phase-appropriate structural characterization and routine analysis of biotherapeutics, including product comparability exercises for clinical- and commercial-stage process improvements. As such, the candidate should have in-depth understanding and commensurate hands-on experience with the biophysical characterization of recombinant proteins, monoclonal antibodies, antibody-drug conjugates, fusion proteins, gene therapy vectors, and/or vaccine products for the proper elucidation of structural elements and molecular size/association properties. Excellent written and communication skills, effective time-management, an innovative spirit, and the ability and desire to work both independently and collaboratively in a multidisciplinary, fast-paced, team-oriented environment are essential for the position.
Candidates should be comfortable working at the interface of analytical chemistry, physical chemistry, biochemistry, cell biology, bioprocess/formulation development, and quality control, as well as participating on cross-functional project teams and interacting with research teams, business units, and commercial manufacturing groups, in an effort to drive molecular design, process/product understanding, and the commercialization of medicines. The candidate will both lead and contribute to cross-functional strategies for the entire department, playing a key role in definition of product quality attributes, characterization/comparability workflows/roadmaps, structure-function assessments, advanced product characterization methodologies, etc. The candidate will serve as a biophysical, biochemistry, and heightened product characterization resource for the department and project teams, proactively keeping colleagues updated with current scientific trends and technical aspects from conferences, local meetings, vendors, and the literature. Lastly, the candidate is highly encouraged to make scientific presentations both internally and externally, as well as publish manuscripts in peer-reviewed journals.
The qualified candidate will lead and manage a biophysical characterization group of 4-8 junior- and senior-level colleagues (including contingent workers and postdoctoral research fellows) with advanced degrees and different areas of specialization. In addition to having matrixed project team and departmental responsibilities, it is expected that the candidate will wholeheartedly encourage and contribute to colleague development both inside and outside their group, as well as build and maintain group infrastructure, and uphold laboratory safety and training. The candidate and their team are highly encouraged to develop novel biophysical approaches and methods with the latest technologies for more informative and efficient product characterization and process monitoring. Demonstrated understanding of the regulatory landscape by the candidate for the biopharmaceutical industry is essential for the biophysical group, project teams, and department, in addition to the candidate's ability to expertly author various sections in regulatory documents and write compelling responses to queries.
Candidates should have previous employment in the pharmaceutical industry, a B.S., M.S., or Ph.D. degree (with 10+, 7+, and 5+ years of work experience, respectively) in biophysics, biochemistry, chemistry, or a related field, and a primary research focus in protein chemistry, structural biology, molecular biophysics, and biological function, commensurate with graduate studies, postdoctoral research, and/or work experience. Previous management experience is highly desired, however, extensive, hands-on experience with the biophysical characterization and analysis of biotherapeutics, involving circular dichroism, differential scanning calorimetry, Fourier transform infrared spectroscopy, fluorescence spectroscopy, size-exclusion chromatography - multi-angle light scattering, and analytical ultracentrifugation, is required. Additional expertise in secondary biophysical techniques, molecular modeling, nuclear magnetic resonance spectroscopy, electron microscopy, X-ray crystallography, mass spectrometry, and/or glycobiology is highly desired. Relevant experience with chromatographic and electrophoretic methods, micro-sample handling techniques, automation via liquid handling robotics, automated data analysis/report generation solutions, statistical analysis, and software development also is expected.
EEO & Employment Eligibility
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Other Job Details:
Last Date to Apply for Job: June 1, 2018
Eligible for Relocation Package: yes
Eligible for Employee Referral Bonus: yes
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.