Pfizer Director Translational Med Lead, Internal Med (MD Required) in Cambridge Kendall Sq. 610 Main, Massachusetts

The Translational Medicine Lead (TML) is a unique leadership role with a dual focus on building translational strategies for projects from LD through POC stage, and also on designing and leading clinical studies in the translational space between bench and bedside. The TML will be responsible for crafting tractable and cohesive biomarker strategies at the asset and platform levels. This will entail identifying translatable biomarkers that can quantatively measure target engagement and disease-pertinent functional modulation, thereby enhancing confidence in clinical relevance and impact. Scope includes identifying clinical parameters to help stratify patient populations and developing new tools to detect signs of clinical therapeutic activity in early clinical studies. The TML may also serve as clinical lead or study clinician on early phase pipeline assets, designing and implementing clinical trials both observational and interventional.

The ideal TML candidate will work directly with scientists within the biology lines to develop quantitative approaches which can be translated to the clinical setting. This position will also leverage existing relationships with partner lines within ECD and PDM to achieve program goals. A key part of the role is liaising with experts in the IMRU fields of research to stay abreast of emerging developments in the field of biomarkers and signs of clinical activity. Candidate will be a member of relevant oversight committees and teams. The candidate will work with teams to develop translational biomarker plans starting at PRISM to ensure that each team has a robust plan in place by the FIH endorsement milestone.


  • Major focus on guiding teams to align preclinical and clinical biomarker strategies

  • Serve as key advisor to above asset biomarker teams (NASH, cachexia, etc)

  • Act as an expert consultant and collaborator working with researchers within the biology and clinical lines to investigate novel translational endpoints

  • Lead and coordinate collaborative efforts to identify translational biomarkers across a range of modalities (e.g. imaging, fluid biomarkers, pan -omics)

  • Coordinate new translational approaches to support the clinical stage IMRU portfolio

  • As a member of relevant oversight committees, ensure that teams have a draft translational plan by LD which will be developed in parallel with efforts to identify a CAN molecule

  • Partner with team leadership (research project lead and clinical lead) to ensure teams develop robust and actionable translational plans to support progression of projects from CAN to SOCA

  • Critical interface with Partner lines such as key groups within ECD (specifically imaging, precision medicine, digital medicine) and PDM (e.g. biomarker group) as well as other RUs where appropriate

  • Leverage relationships with preclinical and clinical statistics groups to ensure biomarker studies are adequately powered to detect anticipated effects.

  • Facilitate the establishment and maintenance of effective collaborations with academic institutions and patient foundations focused on developing quantitative markers of disease

  • May serve as clinical lead or study clinician on clinical phase asset programs


  • MD or MD/PhD with extensive research experience

  • Expertise in one or more of the Internal Medicine disease areas including NASH, T2DM, innate inflammation, cardiometabolic diseases, or eating disorders

  • Excellent communication skills

  • Proven scientific and people leader with demonstrated l eadership experience of both preclinical and clinical projects

  • Capable of driving strategy and influencing others - demonstrates critical scientific thinking, and success at solving complex problems

  • 5-7 years experience in translational science, pharmacology, or medicine within industry or academia with a sound understanding of early clinical development

  • Ability to effectively facilitate meetings and conduct complex, strategic conversations.

  • Track record of innovation and driving effective change

  • Demonstrated success in negotiating the environment of a highly matrix-based organization

  • Established network of academic and industry collaborators

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

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Other Job Details:

  • Eligible for Relocation Package - Yes

  • Eligible for Employee Referral Bonus - Yes

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.