Pfizer Postdoctoral Fellow, Systems Modeling in Cambridge, Massachusetts

Please be sure to submit your cover letter and/or research summary in addition to your CV when applying for this position

The Quantitative Systems Pharmacology (QSP) Lab in Pfizer's Internal Medicine Research Unit (IMRU) is responsible for developing insights to help advance IMRU clinical candidates; identifying and evaluating promising new therapeutic targets through physiologically-based modeling and simulation; and analysis and interpretation of preclinical and clinical data. We seek a highly motivated postdoctoral candidate to develop and analyze mechanistic, mathematical models of cardiac and skeletal muscle mitochondria metabolism to enable the in silico testing of mechanistic hypotheses of metabolic inflexibility with the ultimate goal of improving the identification and evaluation of therapeutic targets for heart failure (HF) and type 2 diabetes mellitus (T2DM).

In addition to enabling in silico identification and assessment of T2DM and HF drug targets, the successful candidate will pursue new avenues for professional development in areas of QSP and MFA modeling, cellular biophysics, data analysis, and uncertainty quantification. The project would involve close interaction with the experimental groups, helping to improve design of metabolic flux analysis (MFA) studies to understand and quantify the contribution of different substrates. The mechanistic insights gained from detailed analyses of the in silico model will generate physiological hypotheses that may be tested experimentally and/or in the clinic. The expectation is that the resulting findings will lead to improved confidence in rationale for the pursuit of novel agents for the treatment of T2DM and HF.

Role Responsibilities

  • Develop validated mathematical models of key pathways underlying mitochondria properties; develop and implement numerical methods for parameter estimation and model simulation

  • Identify, obtain, and organize primary data sets for use in defining parameter values/ranges and for model calibration and validation; contribute to the design of in vitro and in vivo experiments to resolve key knowledge gaps in our understanding of the biology

  • Generate testable hypotheses regarding the pathogenesis and treatment of T2DM and HF at the level of the mitochondria, based on detailed analyses of model and simulation results

  • Present novel results internally and at regional, national and/or international meetings

  • Publish model and simulation results in high-impact journals

Qualifications

  • Recent Ph.D. (0-3 years) in Engineering, Applied Mathematics, Physics or related discipline with strong numerical components focusing on mathematical modeling and simulation. Training and/or experience in mechanistic modeling of biological or physiological systems is preferred.

  • Understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including parameter estimation techniques

  • In-depth understanding of ordinary differential equations (ODEs) and how these can be applied in the development of complex models of biological pathways and systems

  • In-depth, hands-on knowledge of modeling and simulation software (MATLAB, C/C++ preferred)

  • Prior knowledge of and/or experience with Metabolic Flux Analysis (MFA) studies is beneficial

  • Keen interest in learning new areas of biology and building on a solid foundation of quantitative and computational skills

  • Self-directed with ability to work independently

  • Team player

  • Excellent communication and writing skills

  • Primary authorship on relevant publications in peer-reviewed scientific journals

  • Must be willing to relocate to Cambridge, MA, USA

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.