Pfizer Research Fellow, Molecular Model and Simulation in Cambridge, Massachusetts
A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Translational Modeling and Simulation
The successful applicant will lead the East-Coast Translational Modeling and Simulation Group within Pfizer's Medicine Design Organization. The group has a highly visible and sustained track record of delivering translational modeling and simulation to preclinical programs to enable key decisions from early discovery stages through early stage clinical trials. Key impact areas include decisions regarding target prioritization, therapeutic modality selection, drug design, biomarker characterization, chemical optimization, translational strategies and early clinical trial design. The successful applicant will join the Translational Modeling and Simulation Leadership Team which is responsible for the development and implementation of preclinical translational modeling and simulation across every therapeutic area, including platform approaches in systems pharmacokinetics, systems toxicology and cheminformatics.
The successful applicant will lead a group of 3 PhD-level scientists supporting projects across Pfizer's Cardiovascular and Metabolic Disease; Inflammation and Immunology; and Rare Disease areas. A key accountability is to ensure fit-for-purpose quantitative approaches to human translation across every program within these therapeutic areas. Delivery will require hands on support as well as working through direct reports. A core technical component is the development of mathematical models capable of supporting drug design, candidate selection and early clinical development. The successful will establish productive working relationships with key partner groups including: DMPK, biology, medicinal chemistry, clinical pharmacology, precision medicine and drug safety. To this end, excellent communication skills are required in order to properly motivate work plans; gain alignment; and place results in context for decision making. As a manager and leadership team member, the successful applicant will be responsible for direct and indirect mentorship and career development of junior staff. As a senior discipline leader, the successful applicant is expected to remain abreast of the literature as it relates to translational modeling and simulation and to maintain an external presence through regular publication and/or involvement in discipline-leading external organizations.
Ph.D. degree in systems biology, pharmacometrics, pharmaceutical sciences, engineering, mathematics, Physics or similar disciplines where modeling and simulation is emphasized
10+ years of industrial experience in practical applications of modeling and simulation, including direct discovery project support
Extensive contemporary experience in the areas of translational PK-PD modeling and/or systems pharmacology modeling
Experience in the application of translational M&S within one or more of the aforementioned disease areas is desirable
Experience with formal supervision and development of scientific staff.
Experience in the development and implementation of innovative approaches to complex problems at the enterprise level
Experience in leading multidisciplinary teams
Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation
In depth, hands-on knowledge of state-of-the-art modeling and simulation software and applications in the area of PKPD modeling and simulation (e.g. NONMEM, MatLab, Phoenix, Berkeley-Madonna, SAAM II, ADAPT, ACSL, S-plus, R or comparable applications)
Thorough understanding of small molecule pharmacokinetics, including PBPK modeling and simulation
Thorough understanding of quantitative pharmacology
Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of translational PK-PD modeling and simulation
Good team player and communicator
Good listener and ability to effectively interact with colleagues with a variety of backgrounds
Keen to interact as a modeling and simulation expert with multidisciplinary project teams and senior organizational leaders.
Strong belief that preclinical modeling and simulation can have a significant positive impact on research projects
Committed to the development of self and others
Motivated to share technical expertise with others
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Other Job Details:
Last Date to Apply for Job: April 30, 2018
Eligible for Relocation Package: yes
Eligible for Employee Referral Bonus: yes
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.