Pfizer Scientist, Metabolism (non PhD) in Cambridge, Massachusetts
The Internal Medicine Research Unit (IMRU) is committed to finding cures for cardiovascular disease, metabolic diseases and related complications. The Metabolism group is part of IMRU and focused on identifying novel therapies to improve metabolic homeostasis in patients afflicted with these diseases. Our goal is to build a research team of driven scientists focused on developing a deep mechanistic understanding of the metabolic pathways driving Nonalcoholic Steatohepatitis (NASH), cachexia, obesity, diabetes and cardiovascular disease. The aim is to recruit a scientifically and technically strong research scientist proficient in in vivo and in vitro metabolic and inflammation research models. Primary responsibility will be to design and conduct experiments that advance the development of therapies.
Perform ex vivo and in vivo experiments to address key mechanistic and pharmacological scientific questions in cell biology, cellular and physiological metabolism, cell signaling, and inflammation.
Design, complete experimental studies, carry out data analyses and interpretation, record results in electronic lab notebook, and report findings to the team.
Interface with an interdisciplinary team of scientists in the Internal Medicine Research Unit and engage in both target exploration and driving established projects in our portfolio.
Quantify and translate of experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions.
Maintenance of laboratory notebook records and adherence to safety policies is strictly required.
BS with 10+ or MS with 5+ years of experience in pharmacology, cell biology, physiology or immunology.
Deep expertise in cell biology with emphasis on metabolism and signaling pathways is essential.
Experience required in working with inflammatory cells.
Experience required in FACS staining and sorting
Experience required in performing in vivo and ex vivo experiments, including preparing primary cells.
Experience required in mammalian cell cultures, protein and RNA preparation from cells and tissues, Western blot, q-RT-PCR, ELISA, enzymatic assays.
Prior experience in the pharmaceutical setting is strongly desired.
Candidate should be self-motivated, be able to review literature to formulate new ideas, and have the ability to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.
The candidate must be an independent, very organized, and detail oriented scientist and possess strong communication skills.
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Other Job Details:
- Eligible for Employee Referral Bonus
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