Pfizer Senior Associate Scientist, In Vivo Metabolism (Non PhD) in Cambridge, Massachusetts

The Internal Medicine Research Unit (IMRU) is committed to finding cures for cardiovascular disease, metabolic diseases and related complications. The Metabolism group is part of IMRU and focused on identifying novel therapies to improve metabolic homeostasis in patients afflicted with these diseases. Our goal is to build a research team of driven scientists focused on developing a deep mechanistic understanding of the metabolic pathways driving Nonalcoholic Steatohepatitis (NASH), cachexia, obesity, diabetes and cardiovascular disease. The aim is to recruit a scientifically and technically strong research scientist proficient in in vivo and in vitro metabolic research models.

ROLE RESPONSIBILITIES

The successful candidate is expected to possess technical skills in the areas of rodent handling and dietary models of metabolic diseases and to have basic experimental design skills. Primary cell culture experience is desired but not necessary. A desire to understand the underlying causes of metabolic disease, hepatosteatosis, cachexia and basic metabolic pathways involved is essential and we look for driven scientist motivated to have a deep understanding of the development of the diseases.

Successful candidates will be expected to:

  • Perform in vivo experiments to address key mechanistic and pharmacological scientific questions.

  • Have experience with primary cell isolation and cultures.

  • Have experience with FACS staining and sorting.

  • Have experience working with inflammatory cells is a plus.

  • Have experience with experimental design and the interpretation of results.

  • Have basic laboratory skills in the area of quantitative-PCR, molecular biology, western blotting, biochemical assays and tissue processing.

  • Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions.

  • Communicate and present data to the project team

  • Maintenance of laboratory notebook records and adherence to safety policies is strictly required.

QUALIFICATIONS

  • Bachelors with a minimum of 3+ years of experience or a thesis based Master's Degree with 0-3 years of work experience.

  • Possess strong written/verbal communication skills.

  • Drug discovery experience preferred but is not essential.

  • Candidate should be self-motivated and have the ability to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.

EEO & Employment Eligibility

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Other Job Details:

  • Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.