Pfizer Senior Associate Scientist, Metabolism (non PhD) in Cambridge, Massachusetts
The Internal Medicine Research Unit (IMRU) is committed to finding cures for cardiovascular disease, metabolic diseases and related complications. The Metabolism group is part of IMRU and focused on identifying novel therapies to improve metabolic homeostasis in patients afflicted with these diseases. Our goal is to build a research team of driven scientists focused on developing a deep mechanistic understanding of the metabolic pathways driving Nonalcoholic Steatohepatitis (NASH), cachexia, obesity, diabetes and cardiovascular disease. The aim is to recruit a scientifically and technically strong research scientist proficient in in vivo and in vitro metabolic research models.
The successful candidate is expected to possess strong skill sets in cellular and molecular biology; experiences working with primary and immune cells are preferred. In vivo experience and animal handling are desired but not required. Strong oral and written communication skills are required.
Successful candidates will be expected to:
Perform in vitro and ex vivo experiments to explore the mechanism of action of potential biology targets and therapies in various cells.
Analyze in vitro, ex vivo and in vivo samples to assess effects of potential biological targets and therapies, as well as biomarker identification relating to drug action and efficacy.
Develop and validate in vitro assays to support portfolio projects.
Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions.
Communicate and present data to the project team
Maintenance of laboratory notebook records and adherence to safety policies is strictly required.
Bachelors with a minimum of 3+ years of experience or a thesis based Master's Degree with 0-3 years of work experience.
Experience required in mammalian cell culture, protein and RNA preparation from cells and tissues, Western blot, q-RT-PCR, ELISA, enzymatic assays.
Experience with handling primary or immortalized immune cells is preferred, but not required.
Possess strong written/verbal communication skills.
Drug discovery experience preferred but is not essential.
Candidate should be self-motivated and have the ability to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.
EEO & Employment Eligibility
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Last Date to Apply for Job: July 20, 2018
Eligible for Employee Referral Bonus
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This job is Pfizer Exempt US Grade : 004
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