Pfizer Senior Principal Scientist, Modelling and Simulation in Cambridge, Massachusetts

The successful candidate will work within the Biomedicine Design preclinical modeling and simulation team. As a member of multidisciplinary project teams, the candidate will develop and implement quantitative mechanism-based PKPD models which impact the quality of decisions regarding target selection, target prioritization, therapeutic modality selection, biomarker characterization, chemical, biotherapeutic optimization and early clinical trial design.


  • Collaborate with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization and early clinical trial design

  • Liaise with research biology/pharmacology to help in the development of in-vitro assays and in-vivo models to generate data that inform pre-clinical to clinical translated PKPD models

  • Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies

  • Collaborate and maintain an active relationship with Clinical Pharmacology and Pharmacometrics at the project level as well as in the advancement of modeling and simulations sciences

  • Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and therapeutic approaches

  • Keep up to date with emerging literature and science in the systems pharmacology modeling and simulation sciences

  • Continue to build a personal track record of publication in the area of PKPD modeling and simulation and contribute to PDM's external publication/presentation goals consistent with our increased investments in the area of modeling and simulation


  • Ph.D. degree in mathematics, engineering or other disciplines related to quantitative pharmacology with a strong emphasis on biopharmaceutical modeling and simulation.

  • 3-5 years of pharmaceutical industry based experience in developing and applying mechanism-based PKPD models to guide project teams from early discovery to early clinical development.

  • Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation

  • Thorough understanding of the basic principles of pharmacokinetics (non-compartmental, compartmental, PBPK)

  • Leader in the area of modeling and simulation

  • In depth, hands-on knowledge of the state of the art modeling and simulation software and applications in the area of PKPD modeling and simulation (NONMEM, MatLab, Simbiology, Phoenix, Berkeley-Madonna, S-plus, R or comparable applications)

  • Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-relevant PKPD models

  • Ability to translate/condense/summarize outcomes of modeling and simulation analyses into information that can be used by project teams

  • Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of PKPD modeling and simulation

  • Good team player and communicator

  • Good listener and ability to effectively interact with colleagues with a variety of backgrounds

  • Motivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment

  • Keen to interact as a modeling and simulation expert with matrix project teams working closely with departmental, Biology and Clinical scientists

  • Strong belief that modeling and simulation can have a significant positive impact on research projects

  • Committed to the development of self and others

  • Motivated to share technical expertise with others


  • Ideally experience in working in the oncology disease area and with novel therapeutic modalities (bispecifics, CAR-Ts, nano-particles and other targeting agents)


  • Occasional travel, 2-4 times a year, may be needed.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

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Other Job Details:

  • Last Date to Apply for Job: May 12, 2018

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.