Pfizer Sr. Principal Scientist, Molecular Modeling and Simulation in Cambridge, Massachusetts
The successful applicant will be a part of an exceptional translational modeling and simulation team within Pharmacokinetics, Dynamics and Metabolism (PDM) of Medicine Design which applies state-of-the-art modeling and simulation methodologies to preclinical programs to enable key drug discovery decisions from early discovery stages to first-in-human studies. As a member of global multidisciplinary project teams, the candidate will develop and implement quantitative mechanism-based PK-PD models which impact decisions regarding therapeutic modality selection, biomarker characterization, chemical optimization, translational strategies and early clinical trial design.
The successful applicant will have an opportunity to support a range of projects primarily in the oncology therapeutic area, covering small molecules and novel modalities (e.g. nanoparticles). Implementing translational science, such as empirical and/or model-based interspecies scaling of PK-PD and making human dose projections, will be an important task supporting projects transitioning into the clinic. In the earlier phases of drug discovery, development of mechanistic and/or systems pharmacology models will be an essential responsibility for guiding discovery teams to select appropriate compounds and molecular targets. In addition to portfolio support, the successful applicant will aid biologists and experimentalists in implementing emerging methodologies and technologies with respect to the design, execution and interpretation of in vitro and in vivo pharmacology studies.
The successful applicant will have the opportunity to work with multiple stakeholders outside of the modeling and simulation discipline. He/she is also expected to network with global modelers in Translational Modeling and Simulation as well as other groups (Clinical Pharmacology, Pharmacometrics) to share knowledge, work on collaborative projects and enhance consistency in best practices across sites, disease areas, and therapeutic approaches.
The individual is expected to keep up to date with emerging literature and science in modeling and simulation sciences and will have opportunities to present scientific results both internally and externally through conference presentations and publications. Given the global nature of project teams and group members, excellent communication skills, a pro-active approach and independence are essential characteristics for the successful applicant.
Ph.D. degree or equivalent degree in systems biology, pharmacometrics, pharmaceutical sciences, engineering, mathematics, or similar disciplines where modeling and simulation is emphasized.
5+ years of industrial experience in practical applications of modeling and simulation, including direct discovery project support. In particular, extensive experience in the areas of PK-PD modeling and/or systems pharmacology modeling is required. Knowledge of oncology is helpful.
Leadership capacity, strong communication skills, ability to work independently and in teams, and attention to detail are essential.
Direct experience with the phases of drug discovery and development, with particular emphasis on compound selection and translational research issues.
Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation
In depth, hands-on knowledge of state-of-the-art modeling and simulation software and applications in the area of PKPD modeling and simulation (NONMEM, MatLab, Phoenix, Berkeley-Madonna, SAAM II, ADAPT, ACSL, S-plus, R or comparable applications)
Thorough understanding of the basic principles of pharmacokinetics (non-compartmental, compartmental, PBPK)
Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-relevant PK-PD models
Ability to translate/condense/summarize outcomes of modeling and simulation analyses into information that can be used by project teams
Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of PK-PD modeling and simulation
Good team player and communicator that can work well with geographically distributed teams
Able to work in a small team with minimal technical supervision (self-starter)
Good listener and ability to effectively interact with colleagues with a variety of backgrounds
Motivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment
Keen to interact as a modeling and simulation expert with matrix project teams working closely with PDM, Biology and Clinical scientists
Strong belief that modeling and simulation can have a significant positive impact on research projects
Committed to the development of self and others
Motivated to share technical expertise with others
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Other Job Details:
Last Date to Apply for Job: April 15, 2018
Eligible for Relocation Package: yes
Eligible for Employee Referral Bonus: yes
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.