Pfizer Principal Scientist, Protein Degrader Cellular Pharmacology in Groton, Connecticut

We are seeking a highly motivated and skilled individual with strong expertise in molecular and cellular biology to join our Primary Pharmacology group. Specifically, this individual will develop and implement cell-based assays and mechanistic studies to enable our growing Protein degrader platform. This platform focuses on the development of molecules that harness the cell's endogenous ubiquitin-proteasome system to target disease-relevant proteins for degradation. The successful candidate will partner with a cross-disciplinary, and highly-engaged, team of scientists to develop and apply the ideal execution strategies for various programs, and will apply his/her innovative thinking to drive efficiencies and enhance the growth of this exciting drug discovery platform.


  • The successful candidate will join a team of scientists within the larger Discovery Sciences Department that is focused on the identification and optimization of small molecules that target cellular proteins for proteasome-mediated degradation.

  • The individual will apply his/her strong background in cell biology and cellular assays to conduct compound profiling, MoA characterization, and SAR development. These efforts will rely on the candidate to develop and apply a broad suite of assays which include quantifying cellular protein levels, evaluating target engagement and ternary complex formation, and assessing cellular function, all with the goal of driving compound progression across various disease areas of focus.

  • This individual will collaborate across multiple groups, and will be asked to bring strategic insight into the design of assays and screening funnels to optimize program progression.

  • Additionally, he/she will maintain a strong and current knowledge base in the Ubiquitin-Proteasome system and E3 ligase biology to guide the development of novel and innovative approaches that will help us advance this new drug discovery platform.

Successful candidates will be expected to:

  • Have hands-on experience in conducting cellular assays to quantify changes in protein levels, such as Western blotting, HTRF, AlphaScreen, MSD, ELISA, and immunflourescence, etc.

  • Have experience across a broad range of cell-based assays aimed at evaluating target engagement, ternary complex formation, and downstream signaling pathway endpoints.

  • Possess a current and strong knowledge in the area of proteasome-mediated degradation and E3-mediated ubiquitination.

  • Be proficient in designing experiments to address key scientific questions, and demonstrate an ability to analyze and interpret experimental results, and to communicate these results effectively to program teams.

  • Lead efforts to identify, evaluate, and implement new technologies and methods that can advance efforts in developing protein degrader molecules.

  • Have a current grasp of academic and industry activities in the field of protein degradation and small molecule intervention, and incorporate knowledge into value-added, enabling platform developments.

  • Show clear evidence of future mentoring and leadership potential.

  • Promote Pfizer's capabilities and reputation through external publications and presentations.

  • Maintain up to date electronic laboratory notebooks and records in accordance with Pfizer policy.

  • Comply with all safety training and good laboratory practices.

  • Be highly motivated, highly organized and possess excellent verbal and written communication skills.

  • Show significant ability to work effectively in a matrixed, team-oriented environment.


  • Minimum qualification: PhD or equivalent in biomedical research or biotech/pharma with at least 4 years of relevant experience OR MSc/BSc with 8+ years of relevant industry experience

  • Strong assay development skills in the areas of gene and protein expression, target engagement, signaling pathway read-outs, and ternary complex formation

  • Experience with troubleshooting technical assays and protocols

  • Demonstration of excellent computer, verbal and written communication skills.

  • Demonstrated examples of personal and scientific leadership

  • Have a sustained track record of delivering high quality data meeting the needs of teams

  • Experience of successfully interacting with and meeting the needs of stakeholder groups is essential as well as having a customer focus

  • Ability to multi-task and to balance bench and desk activities

  • Strong team-oriented focus


  • Deep and current knowledge in E3 ligase biology and cellular machinery for protein degradation

  • Experience with plate-based mid- to high-throughput cell-based pharmacology assays

  • Experience managing or mentoring junior colleagues or peers


  • Travel mostly restricted to occasional trips to Cambridge, MA, or less frequently, to La Jolla, CA to partner with Research Unit project teams and to attend appropriate meetings and conferences

  • Compliance with laboratory safety practices

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

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Other Job Details:

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.