Pfizer Scientist (non in La Jolla, California
We seek a non-PhD scientist to join the in vivo pharmacology group within Pfizer Oncology Research & Development (ORD) in La Jolla, California. The successful candidate will join a dynamic team of scientists in the Oncology In Vivo Pharmacology Group, contributing to the characterization of models of cancer and evaluating new drug candidates.
Participate in pre-clinical drug discovery and development projects with a focus on targeted therapeutics, epigenetics and the tumor microenvironment. Characterize and develop small molecules in close collaboration with partner lines as a member of drug discovery teams. Evaluate anti-tumor effects in combination with biologics. Employ and contribute to developing new cutting-edge in vivo mouse and human cancer models. Provide technical and scientific skill in in vivo pharmacology to the tumor cell biology department to enable target identification, validation, prioritization and efficient drug discovery of small molecules.
Ideal applicants will have a background in immunology, excellent communication and organizational skills, critical problem-solving abilities, and a commitment to excellence.
Plan, execute and analyze multi-parameter flow cytometric analysis studies of cells within the tumor microenvironment.
Responsible for building and continuously updating flow panels based on recent scientific advances. Maintenance and upgrade of equipment (Fortessa-X20).
Characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel therapies.
Conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Interpretation, presentation and documentation of experiments.
Presentation of results within a multidisciplinary team environment.
BS degree in Cancer Biology, Immunology or related discipline with 6+ years', or MS with 5+ years', relevant work experience.
Experience in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20, Cytobank, FlowJo, FACS, MACS).
Experience with animal models of human cancers.
Hands on in vivo skills (IV, PO dosing), blood/tissue collection
Ability to follow novel scientific or technological developments, and to implement them in the laboratory.
Current knowledge of oncology research, drug discovery and development.
Excellent written and oral communication and presentation skills in English.
Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.
Experience with operating a cell sorter is a plus
- Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
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Eligible for Employee Referral Bonus
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