Pfizer Principal Scientist, Targeted Immunotherapy in Pearl River, New York

The Targeted Immunotherapy (TI) group within the Targeted Therapeutics Discovery (TTD) department has an opening for an enthusiastic, inquisitive, and creative cancer immunologist. The successful applicant will play a fundamental role in the implementation of TTD/TI strategy in the discovery and development of T cell bispecifics/multispecifics for immune cell retargeting and immune modulation. The incumbent will serve as a project leader applying their cancer immunology expertise to manage the scientific & strategic needs of the programs. Experience investigating mechanisms regulating T cell mediated immune responses and resistance mechanisms to redirected T cell therapies or immunotherapies is a significant plus. The successful candidate will have opportunities to propose/establish immune cell retargeting research projects and he/she is expected to collaborate with other program leaders and partner lines. The successful candidate will demonstrate a proven track record of scientific productivity as evidenced by first author publications in prominent journals. The candidate will demonstrate his/her ability to participate in a highly matrixed and innovative research environment. The successful applicant will be able to translate basic research findings into therapeutic strategies. The individual will be expected to participate in strategic discussions with department leadership. He/She will manage their own time to meet agreed targets, will develop plans for their own projects (timelines, work plans, deliverables) and will take a proactive role in their personal growth and scientific development.

Additional Job Description

  • Focused work in tumor and immune cell target identification/validation leading to innovative next generation biologics and modalities

  • Utilize expertise to independently design, execute and analyze experiments using cellular and molecular immunological assays to investigate/uncover novel target biology and mechanisms-of-action relating to immune cell retargeting biologics

  • Explore, develop and apply novel in vitro assay systems that are predictive of immune mechanisms of cancer in vivo

  • Effectively collaborate with other members of the Oncology group and supporting collaborators and partner lines

  • Prepare and present hypotheses, on-going progress, technical reports and future plans to project teams, governance bodies, and departmental/research unit/site/global level meetings within Pfizer

  • Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetings and conferences

  • Contribute to building a culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders, and continuous learning/improvement.


  • Ph.D. degree in Immunology, Cancer Biology, Cell Biology or a related field with 4+ years of experience working in the field of immunology or tumor immunology with associated publication record

  • Robust understanding of innate and adaptive immune systems is required

  • Strong biological and technical knowledge/experience with expertise in conventional immunological techniques is required

  • Experience in T cell function/differentiation/signaling/regulation, phenotypic analysis of inhibitory and costimulatory targets and pathways and/or immune cell retargeting bispecifics is highly preferred

  • Pro-active attitude to discover novel biology and potential new drugs for the treatment of cancer

  • Excellent communication skills (both written and oral) with capability to work both independently and collaboratively

  • Highly organized in terms of independent goal setting and diligence in advancing projects towards those goals

Other Job Details:

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

EEO & Employment Eligibility

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