Pfizer Senior Scientist, Early Bioprocess Development in Pearl River, New York
The selected colleague will develop conjugation processes for conjugate vaccines from peptides, proteins, polysaccharides and produce immunological reagents using diverse techniques and tools from biochemistry and chemistry, including various purification techniques. Knowledge and experience using nanoparticles and virus like particles (VLPs) as vaccine candidates is a plus These include implementation of processes for polysaccharide derivatives, proteins, multiprotein complexes, virus like particles and nanoparticles using broad range of bioconjugation strategies and fractionation methods and chromatographic techniques. It is also expected that the incumbent will perform analysis / characterization of isolated macromolecules with various bioanalytical / biophysical methodologies. Careful documentation of work and data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.
Develop processes for conjugate vaccines using a variety of bioconjugation, carbohydrate, peptide and protein chemistry technologies
Develop purification processes for conjugate vaccines using a variety of ultra/diafiltration, etc., and chromatographic techniques (affinity, ion exchange, hydrophobic interaction, etc).
In-process characterization and analysis of carbohydrates, peptides, nanoparticles, proteins and conjugate vaccines using a variety of chmromatographic methods, colorimetric and spectrometric techniques such as NMR, mass spectrometry, light scattering, capillary electrophoresis and protein chemistry technologies
Analyze, document and interpret scientific research and technical data. Author and review technical documents, reports, production records, technology transfer reports
Develop and present data in internal as well as external meetings and management.
Knowledge of regulatory frameworks such as chemistry, manufacturing and control (CMC) and cGMP environments.
Follow all Pfizer safety, training and laboratory research guidelines to work in compliance with all regulations and standard procedures.
Ph D in Chemistry or Biochemistry with 0-2 years of postdoctoral experience, preferably in a Biopharmaceutical or Vaccine industry environment
MS in Chemistry or Biochemistry with 5-7 years of experience, preferably in a Biopharmaceutical/Vaccine industry environment
Proficient in handling peptides, proteins, carbohydrates, polysaccharides and nanoparticles
Proficient in bioconjugation techniques and protein chemistry technologies as they related conjugate vaccine development.
Experienced in large scale purification processes applicable to peptides, proteins, polysaccharides, nanoparticles and bioconjugates. Proficient in chromatographic purification, ultrafiltration/diafiltration, separation of macromolecules, virus like particles and nanoparticles
Experienced in bioprocess development, scale-up and technology transfer to clinical trial manufacturing facilities.
Well versed in analytical and bioanalytical techniques applicable to peptides, proteins, carbohydrates, bioconjugates: NMR, mass spectrometry, light scattering, HPLC, colorimetric techniques, etc.
Familiarity with cGMP and current chemistry, manufacturing and control (CMC) regulatory framework.
Excellent written and oral skills and technical writing, documentation
Ability to perform laboratory experiments and perform complex scientific data analysis
EEO & Employment Eligibility
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