Pfizer Senior Scientist, Early Bioprocess Development in Pearl River, New York

The selected colleague will develop conjugation processes for conjugate vaccines from peptides, proteins, polysaccharides and produce immunological reagents using diverse techniques and tools from biochemistry and chemistry, including various purification techniques. Knowledge and experience using nanoparticles and virus like particles (VLPs) as vaccine candidates is a plus These include implementation of processes for polysaccharide derivatives, proteins, multiprotein complexes, virus like particles and nanoparticles using broad range of bioconjugation strategies and fractionation methods and chromatographic techniques. It is also expected that the incumbent will perform analysis / characterization of isolated macromolecules with various bioanalytical / biophysical methodologies. Careful documentation of work and data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

Role Responsibilities

  • Develop processes for conjugate vaccines using a variety of bioconjugation, carbohydrate, peptide and protein chemistry technologies

  • Develop purification processes for conjugate vaccines using a variety of ultra/diafiltration, etc., and chromatographic techniques (affinity, ion exchange, hydrophobic interaction, etc).

  • In-process characterization and analysis of carbohydrates, peptides, nanoparticles, proteins and conjugate vaccines using a variety of chmromatographic methods, colorimetric and spectrometric techniques such as NMR, mass spectrometry, light scattering, capillary electrophoresis and protein chemistry technologies

  • Analyze, document and interpret scientific research and technical data. Author and review technical documents, reports, production records, technology transfer reports

  • Develop and present data in internal as well as external meetings and management.

  • Knowledge of regulatory frameworks such as chemistry, manufacturing and control (CMC) and cGMP environments.

  • Follow all Pfizer safety, training and laboratory research guidelines to work in compliance with all regulations and standard procedures.

Qualifications

  • Ph D in Chemistry or Biochemistry with 0-2 years of postdoctoral experience, preferably in a Biopharmaceutical or Vaccine industry environment

  • MS in Chemistry or Biochemistry with 5-7 years of experience, preferably in a Biopharmaceutical/Vaccine industry environment

  • Proficient in handling peptides, proteins, carbohydrates, polysaccharides and nanoparticles

  • Proficient in bioconjugation techniques and protein chemistry technologies as they related conjugate vaccine development.

  • Experienced in large scale purification processes applicable to peptides, proteins, polysaccharides, nanoparticles and bioconjugates. Proficient in chromatographic purification, ultrafiltration/diafiltration, separation of macromolecules, virus like particles and nanoparticles

  • Experienced in bioprocess development, scale-up and technology transfer to clinical trial manufacturing facilities.

  • Well versed in analytical and bioanalytical techniques applicable to peptides, proteins, carbohydrates, bioconjugates: NMR, mass spectrometry, light scattering, HPLC, colorimetric techniques, etc.

  • Familiarity with cGMP and current chemistry, manufacturing and control (CMC) regulatory framework.

  • Excellent written and oral skills and technical writing, documentation

PHYSICAL/MENTAL REQUIREMENTS

Ability to perform laboratory experiments and perform complex scientific data analysis

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.