Pfizer Senior Principal Scientist, Cancer Systems Biology in United States
Cancer progression is a manifestation of genetically induced changes in the dynamic interaction of many cellular components. To guide precision medicine discovery campaigns at Pfizer, t he newly formed Cancer Systems Therapeutics group located in La Jolla will develop cutting-edge systems biology tools to quantify global cellular perturbations induced by oncogenic changes and by small molecules aimed at counteracting such changes. Team members will apply systems biology-based disciplines to identify novel intervention targets with genetic- and chemistry-first approaches and to deepen our understanding of anti-cancer programs under development.
We are seeking an expert in systems biology, with sound knowledge of target identification and validation in a drug discovery context. This is an exciting opportunity to apply cutting-edge methods and contribute to the target portfolios of the disease Research Units of one of the world's leading developers of novel therapeutics.
Manage the cancer systems biology group and its screening projects, and direct associate personnel
Maintain close and productive interactions with the systems biology-related groups throughout the organization
Contribute expertise to help shape the target identification and validation strategies of the Tumor Cell Biology group
Develop tool assets for dovetailing chemical biology, genetics, molecular profiling, and computational biology discovery strategies to advance a small molecule portfolio
Work with and manage relationships with external contract providers
Stay current with systems biology technologies including those relating to genome-editing, chemical biology, and proteomics
Contribute to building a culture that embraces continuous learning and improvement
Help to establish the systems biology group as an integral component of world-wide research development
Influence disease Research Unit portfolios through delivery of screening results, follow-up studies, and associated insights
4-6 reports including people managers. Expected to display strong supervisory skills, providing coaching, development, and feedback for other colleagues. Will educate project team on appropriate interpretation of discipline scientific results.
PhD in molecular biology or related field, with significant experience and expertise in systems biology
Postdoctoral experience and at least 8 years additional experience in an industrial or academic setting, with experience in project management
Track record of innovative and impactful research including peer-reviewed publications, preferably with systems biology relevant methodologies
Significant experience with an array of molecular and cell biology methods, including those required for executing large pooled or arrayed molecular library screens, constructing CRISPR-based libraries, and prioritizing results from large functional genomics or chemical screens
A strong background in cell biology and familiarity with bioinformatics and computational approaches to target discovery
Experience with managing a laboratory and directing the activities of more junior personnel
Ability to effectively interact and communicate with multidisciplinary scientists, both internally and externally; excellent communication, interpersonal, and presentation skills essential
Demonstrated ability to identify, evaluate, propose and develop new experimental approaches
Other Job Details:
Eligible for Employee Referral Bonus
Eligible for Relocation Package
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